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An update on the latest clinical trial results of HDL and the role of HDL in preventing atherosclerotic disease

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by Dr Jamie Morton

Numerous epidemiological and preclinical studies have shown that higher HDL levels are atheroprotective, which is thought to be due to not only the role of HDL in cholesterol efflux, but also its powerful anti-inflammatory and anti-oxidant properties.

However, in the last few years several landmark clinical trials employing HDL-raising as a therapeutic strategy have failed to demonstrate a clinical benefit for cardiovascular disease.

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